Chronic Wasting Disease CWD roundup

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Chronic Wasting Disease CWD roundup

Postby flounder » Mon Mar 28, 2016 10:05 am

OUT OF CONTROL AND SPREADING !


the maximum total urls allowed are 6, so I cannot post all the states that are battling CWD TSE Prion. but this is very concerning to say the least. you cattle ranchers better pray that this CWD TSE prion does not mutate over into cattle, and don’t think for one minute this cannot or has not happened yet. carry on...


Thursday, March 24, 2016

ARKANSAS FIRST BATCH OF TARGET TESTS REVEALS 19 ADDITIONAL CWD-POSITIVE CERVIDS

http://chronic-wasting-disease.blogspot ... tests.html

Wednesday, March 16, 2016

Wisconsin CWD sample survey 2015 confirms 290 cases of Chronic Wasting Disease TSE Prion

http://chronic-wasting-disease.blogspot ... -2015.html

Thursday, March 10, 2016

WYOMING RIDE EM COWBOY HELICOPTER WRANGLING RAMBO STYLE DEER BULLDOGGING RODEO FOR CWD VIDEO

CHRONIC WASTING DISEASE: The Final Epidemic

http://chronic-wasting-disease.blogspot ... opter.html

Wednesday, March 02, 2016

Kansas Chronic Wasting Disease CWD TSE Prion 52 cases 2015 updated report 'ALARMING'

http://chronic-wasting-disease.blogspot ... d-tse.html

Friday, February 26, 2016

TEXAS Hartley County Mule Deer Tests Positive for Chronic Wasting Disease CWD TSE Prion

http://chronic-wasting-disease.blogspot ... tests.html

Sunday, March 20, 2016

Docket No. FDA-2003-D-0432 (formerly 03D-0186) Use of Material from Deer and Elk in Animal Feed ***UPDATED MARCH 2016*** Singeltary Submission

http://chronic-wasting-disease.blogspot ... y-03d.html
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Re: Chronic Wasting Disease CWD roundup

Postby M.Magis » Mon Mar 28, 2016 10:43 am

You’re 10 years late learning about CWD. It’s been known about for decades. And it’s proven itself to be a non-issue, though a handful of misguided idiots cried wolf a few years back and convinced a lot of people there was something to worry about. It kills a small fraction that EHD kills, and there has never been a case of it transferring to any other animal. If you’re going to copy and paste scare articles, try to read and understand the content first to prevent making yourself look foolish.

Look who I’m talking to….
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Re: Chronic Wasting Disease CWD roundup

Postby flounder » Mon Mar 28, 2016 10:49 am

M.Magis wrote:You’re 10 years late learning about CWD. It’s been known about for decades. And it’s proven itself to be a non-issue, though a handful of misguided idiots cried wolf a few years back and convinced a lot of people there was something to worry about. It kills a small fraction that EHD kills, and there has never been a case of it transferring to any other animal. If you’re going to copy and paste scare articles, try to read and understand the content first to prevent making yourself look foolish.

Look who I’m talking to….




LMAO!!!



PRION 2015 CONFERENCE FT. COLLINS CWD RISK FACTORS TO HUMANS

*** LATE-BREAKING ABSTRACTS PRION 2015 CONFERENCE ***

O18

Zoonotic Potential of CWD Prions

Liuting Qing1, Ignazio Cali1,2, Jue Yuan1, Shenghai Huang3, Diane Kofskey1, Pierluigi Gambetti1, Wenquan Zou1, Qingzhong Kong1 1Case Western Reserve University, Cleveland, Ohio, USA, 2Second University of Naples, Naples, Italy, 3Encore Health Resources, Houston, Texas, USA

*** These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection.

==================

***These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection.***

==================

P.105: RT-QuIC models trans-species prion transmission

Kristen Davenport, Davin Henderson, Candace Mathiason, and Edward Hoover Prion Research Center; Colorado State University; Fort Collins, CO USA

Conversely, FSE maintained sufficient BSE characteristics to more efficiently convert bovine rPrP than feline rPrP. Additionally, human rPrP was competent for conversion by CWD and fCWD.

***This insinuates that, at the level of protein:protein interactions, the barrier preventing transmission of CWD to humans is less robust than previously estimated.

================

***This insinuates that, at the level of protein:protein interactions, the barrier preventing transmission of CWD to humans is less robust than previously estimated.***

================

https://prion2015.files.wordpress.com/2 ... guide1.pdf

*** PRICE OF CWD TSE PRION POKER GOES UP 2014 ***

Transmissible Spongiform Encephalopathy TSE PRION update January 2, 2014

*** chronic wasting disease, there was no absolute barrier to conversion of the human prion protein.

*** Furthermore, the form of human PrPres produced in this in vitro assay when seeded with CWD, resembles that found in the most common human prion disease, namely sCJD of the MM1 subtype.

http://wwwnc.cdc.gov/eid/article/20/1/1 ... rticle.htm

http://chronic-wasting-disease.blogspot ... notic.html

*** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).***

https://www.landesbioscience.com/journa ... =112223249

*** The potential impact of prion diseases on human health was greatly magnified by the recognition that interspecies transfer of BSE to humans by beef ingestion resulted in vCJD. While changes in animal feed constituents and slaughter practices appear to have curtailed vCJD, there is concern that CWD of free-ranging deer and elk in the U.S. might also cross the species barrier. Thus, consuming venison could be a source of human prion disease. Whether BSE and CWD represent interspecies scrapie transfer or are newly arisen prion diseases is unknown. Therefore, the possibility of transmission of prion disease through other food animals cannot be ruled out. There is evidence that vCJD can be transmitted through blood transfusion. There is likely a pool of unknown size of asymptomatic individuals infected with vCJD, and there may be asymptomatic individuals infected with the CWD equivalent. These circumstances represent a potential threat to blood, blood products, and plasma supplies.

http://cdmrp.army.mil/prevfunded/nprp/N ... Report.pdf
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Re: Chronic Wasting Disease CWD roundup

Postby flounder » Mon Mar 28, 2016 10:54 am

WITH TSE PRIONS, never say never...


Conclusions. To our knowledge, this is the first established experimental model of CWD in TgSB3985. We found evidence for co-existence or divergence of two CWD strains adapted to Tga20 mice and their replication in TgSB3985 mice. Finally, we observed phenotypic differences between cervid-derived CWD and CWD/Tg20 strains upon propagation in TgSB3985 mice. Further studies are underway to characterize these strains.


http://chronic-wasting-disease.blogspot ... nt-of.html


----- Original Message -----


From: David Colby To: flounder9@verizon.net


Cc: stanley@XXXXXXXX


Sent: Tuesday, March 01, 2011 8:25 AM


Subject: Re: FW: re-Prions David W. Colby1,* and Stanley B. Prusiner1,2 + Author Affiliations


Dear Terry Singeltary,


Thank you for your correspondence regarding the review article Stanley Prusiner and I recently wrote for Cold Spring Harbor Perspectives. Dr. Prusiner asked that I reply to your message due to his busy schedule. We agree that the transmission of CWD prions to beef livestock would be a troubling development and assessing that risk is important. In our article, we cite a peer-reviewed publication reporting confirmed cases of laboratory transmission based on stringent criteria. The less stringent criteria for transmission described in the abstract you refer to lead to the discrepancy between your numbers and ours and thus the interpretation of the transmission rate. We stand by our assessment of the literature--namely that the transmission rate of CWD to bovines appears relatively low, but we recognize that even a low transmission rate could have important implications for public health and we thank you for bringing attention to this matter. Warm Regards, David Colby -- David Colby, PhDAssistant Professor Department of Chemical Engineering University of Delaware

===========END...TSS==============


SNIP...SEE FULL TEXT ;


http://betaamyloidcjd.blogspot.com/2011 ... -like.html


http://chronic-wasting-disease.blogspot ... nt-of.html


”The occurrence of CWD must be viewed against the contest of the locations in which it occurred. It was an incidental and unwelcome complication of the respective wildlife research programmes. Despite it’s subsequent recognition as a new disease of cervids, therefore justifying direct investigation, no specific research funding was forthcoming. The USDA veiwed it as a wildlife problem and consequently not their province!” page 26.

http://collections.europarchive.org/tna ... /tab01.pdf

In Confidence - Perceptions of unconventional slow virus diseases of animals in the USA - APRIL-MAY 1989 - G A H Wells

3. Prof. A. Robertson gave a brief account of BSE. The US approach was to accord it a very low profile indeed. Dr. A Thiermann showed the picture in the ''Independent'' with cattle being incinerated and thought this was a fanatical incident to be avoided in the US at all costs. ...

http://web.archive.org/web/200603070635 ... /tab01.pdf

AND THEY MEANT IT $$$
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Re: Chronic Wasting Disease CWD roundup

Postby TennesseeTuxedo » Mon Mar 28, 2016 3:04 pm

Don't feed the troll.
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Re: Chronic Wasting Disease CWD roundup

Postby flounder » Mon Apr 04, 2016 3:37 pm

Saturday, April 02, 2016

TEXAS TAHC BREAKS IT'S SILENCE WITH TWO MORE CASES CWD CAPTIVE DEER BRINGING TOTAL TO 10 CAPTIVES REPORTED TO DATE

http://chronic-wasting-disease.blogspot ... h-two.html

Friday, April 01, 2016

ARKANSAS CHRONIC WASTING DISEASE CWD TSE PRION CASES EXPLODE BY 27 NEW CASES WITH 50 CASES TOTAL TO DATE

http://chronic-wasting-disease.blogspot ... e-cwd.html

Friday, April 01, 2016

Arkansas confirms six more cases of CWD bringing total to 56 since first reported 2 months ago

http://chronic-wasting-disease.blogspot ... f-cwd.html

Thursday, March 31, 2016

Chronic Wasting Disease CWD TSE Prion Roundup USA April 1, 2016

http://chronic-wasting-disease.blogspot ... prion.html

I strenuously once again urge the FDA and its industry constituents, to make it MANDATORY that all ruminant feed be banned to all ruminants, and this should include all cervids, as well as non-ruminants such as cats and dogs as well, as soon as possible for the following reasons...

31 Jan 2015 at 20:14 GMT

*** Ruminant feed ban for cervids in the United States? ***

31 Jan 2015 at 20:14 GMT

see Singeltary comment ;

http://www.plosone.org/annotation/listT ... root=85351
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Re: Chronic Wasting Disease CWD roundup

Postby flounder » Mon Apr 04, 2016 3:38 pm

YEP, just a matter of time and strain...tss




Monday, April 04, 2016

Limited amplification of chronic wasting disease prions in the peripheral tissues of intracerebrally inoculated cattle

http://chronic-wasting-disease.blogspot ... ronic.html



tss
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Re: Chronic Wasting Disease CWD roundup

Postby hopalong » Thu May 05, 2016 8:32 am

The sky is falling,,,, The sky is falling<<<
Terry did they ever really determine why you mother died other than embarrassment about you ????
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Re: Chronic Wasting Disease CWD roundup

Postby flounder » Thu May 05, 2016 9:54 am

hopalong wrote:The sky is falling,,,, The sky is falling<<<
Terry did they ever really determine why you mother died other than embarrassment about you ????


yes, Heidenhain Variant Creutzfeldt Jakob disease hvCJD, confirmed. you see, I had her brain taken out to help for science, to help save humans, and the likes of folks like you even there hopalong...carry on Sir.

PRION 2016 TOKYO

Zoonotic Potential of CWD Prions: An Update

Ignazio Cali1, Liuting Qing1, Jue Yuan1, Shenghai Huang2, Diane Kofskey1,3, Nicholas Maurer1, Debbie McKenzie4, Jiri Safar1,3,5, Wenquan Zou1,3,5,6, Pierluigi Gambetti1, Qingzhong Kong1,5,6

1Department of Pathology, 3National Prion Disease Pathology Surveillance Center, 5Department of Neurology, 6National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

4Department of Biological Sciences and Center for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada,

2Encore Health Resources, 1331 Lamar St, Houston, TX 77010

Chronic wasting disease (CWD) is a widespread and highly transmissible prion disease in free-ranging and captive cervid species in North America. The zoonotic potential of CWD prions is a serious public health concern, but the susceptibility of human CNS and peripheral organs to CWD prions remains largely unresolved. We reported earlier that peripheral and CNS infections were detected in transgenic mice expressing human PrP129M or PrP129V. Here we will present an update on this project, including evidence for strain dependence and influence of cervid PrP polymorphisms on CWD zoonosis as well as the characteristics of experimental human CWD prions.

PRION 2016 TOKYO

In Conjunction with Asia Pacific Prion Symposium 2016

PRION 2016 Tokyo

Prion 2016

Prion. 10:S15-S21. 2016 ISSN: 1933-6896 printl 1933-690X online

Taylor & Francis

Prion 2016 Animal Prion Disease Workshop Abstracts

WS-01: Prion diseases in animals and zoonotic potential

Juan Maria Torres a, Olivier Andreoletti b, J uan-Carlos Espinosa a. Vincent Beringue c. Patricia Aguilar a,

Natalia Fernandez-Borges a. and Alba Marin-Moreno a

"Centro de Investigacion en Sanidad Animal ( CISA-INIA ). Valdeolmos, Madrid. Spain; b UMR INRA -ENVT 1225 Interactions Holes Agents Pathogenes. ENVT. Toulouse. France: "UR892. Virologie lmmunologie MolécuIaires, Jouy-en-Josas. France

Dietary exposure to bovine spongiform encephalopathy (BSE) contaminated bovine tissues is considered as the origin of variant Creutzfeldt Jakob (vCJD) disease in human. To date, BSE agent is the only recognized zoonotic prion. Despite the variety of Transmissible Spongiform Encephalopathy (TSE) agents that have been circulating for centuries in farmed ruminants there is no apparent epidemiological link between exposure to ruminant products and the occurrence of other form of TSE in human like sporadic Creutzfeldt Jakob Disease (sCJD). However, the zoonotic potential of the diversity of circulating TSE agents has never been systematically assessed. The major issue in experimental assessment of TSEs zoonotic potential lies in the modeling of the ‘species barrier‘, the biological phenomenon that limits TSE agents’ propagation from a species to another. In the last decade, mice genetically engineered to express normal forms of the human prion protein has proved essential in studying human prions pathogenesis and modeling the capacity of TSEs to cross the human species barrier.

To assess the zoonotic potential of prions circulating in farmed ruminants, we study their transmission ability in transgenic mice expressing human PrPC (HuPrP-Tg). Two lines of mice expressing different forms of the human PrPC (129Met or 129Val) are used to determine the role of the Met129Val dimorphism in susceptibility/resistance to the different agents.

These transmission experiments confirm the ability of BSE prions to propagate in 129M- HuPrP-Tg mice and demonstrate that Met129 homozygotes may be susceptible to BSE in sheep or goat to a greater degree than the BSE agent in cattle and that these agents can convey molecular properties and neuropathological indistinguishable from vCJD. However homozygous 129V mice are resistant to all tested BSE derived prions independently of the originating species suggesting a higher transmission barrier for 129V-PrP variant.

Transmission data also revealed that several scrapie prions propagate in HuPrP-Tg mice with efficiency comparable to that of cattle BSE. While the efficiency of transmission at primary passage was low, subsequent passages resulted in a highly virulent prion disease in both Met129 and Val129 mice. Transmission of the different scrapie isolates in these mice leads to the emergence of prion strain phenotypes that showed similar characteristics to those displayed by MM1 or VV2 sCJD prion. These results demonstrate that scrapie prions have a zoonotic potential and raise new questions about the possible link between animal and human prions.

http://www.tandfonline.com/na101/home/l ... fp.png_v03

Research Project: TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES

Title: Transmission of scrapie prions to primate after an extended silent incubation period

Authors

item Comoy, Emmanuel - item Mikol, Jacqueline - item Luccantoni-Freire, Sophie - item Correia, Evelyne - item Lescoutra-Etchegaray, Nathalie - item Durand, Valérie - item Dehen, Capucine - item Andreoletti, Olivier - item Casalone, Cristina - item Richt, Juergen item Greenlee, Justin item Baron, Thierry - item Benestad, Sylvie - item Hills, Bob - item Brown, Paul - item Deslys, Jean-Philippe -

Submitted to: Scientific Reports Publication Type: Peer Reviewed Journal Publication Acceptance Date: May 28, 2015 Publication Date: June 30, 2015 Citation: Comoy, E.E., Mikol, J., Luccantoni-Freire, S., Correia, E., Lescoutra-Etchegaray, N., Durand, V., Dehen, C., Andreoletti, O., Casalone, C., Richt, J.A., Greenlee, J.J., Baron, T., Benestad, S., Brown, P., Deslys, J. 2015. Transmission of scrapie prions to primate after an extended silent incubation period. Scientific Reports. 5:11573.

Interpretive Summary: The transmissible spongiform encephalopathies (also called prion diseases) are fatal neurodegenerative diseases that affect animals and humans. The agent of prion diseases is a misfolded form of the prion protein that is resistant to breakdown by the host cells. Since all mammals express prion protein on the surface of various cells such as neurons, all mammals are, in theory, capable of replicating prion diseases. One example of a prion disease, bovine spongiform encephalopathy (BSE; also called mad cow disease), has been shown to infect cattle, sheep, exotic undulates, cats, non-human primates, and humans when the new host is exposed to feeds or foods contaminated with the disease agent. The purpose of this study was to test whether non-human primates (cynomologous macaque) are susceptible to the agent of sheep scrapie. After an incubation period of approximately 10 years a macaque developed progressive clinical signs suggestive of neurologic disease. Upon postmortem examination and microscopic examination of tissues, there was a widespread distribution of lesions consistent with a transmissible spongiform encephalopathy. This information will have a scientific impact since it is the first study that demonstrates the transmission of scrapie to a non-human primate with a close genetic relationship to humans. This information is especially useful to regulatory officials and those involved with risk assessment of the potential transmission of animal prion diseases to humans. Technical Abstract: Classical bovine spongiform encephalopathy (c-BSE) is an animal prion disease that also causes variant Creutzfeldt-Jakob disease in humans. Over the past decades, c-BSE's zoonotic potential has been the driving force in establishing extensive protective measures for animal and human health.

*** In complement to the recent demonstration that humanized mice are susceptible to scrapie, we report here the first observation of direct transmission of a natural classical scrapie isolate to a macaque after a 10-year incubation period. Neuropathologic examination revealed all of the features of a prion disease: spongiform change, neuronal loss, and accumulation of PrPres throughout the CNS.

*** This observation strengthens the questioning of the harmlessness of scrapie to humans, at a time when protective measures for human and animal health are being dismantled and reduced as c-BSE is considered controlled and being eradicated.

*** Our results underscore the importance of precautionary and protective measures and the necessity for long-term experimental transmission studies to assess the zoonotic potential of other animal prion strains.

http://www.ars.usda.gov/research/public ... 115=313160

Saturday, April 23, 2016

SCRAPIE WS-01: Prion diseases in animals and zoonotic potential 2016

Prion. 10:S15-S21. 2016 ISSN: 1933-6896 printl 1933-690X online

http://scrapie-usa.blogspot.com/2016/04 ... imals.html

In Confidence - Perceptions of unconventional slow virus diseases of animals in the USA - APRIL-MAY 1989 - G A H Wells

3. Prof. A. Robertson gave a brief account of BSE. The US approach was to accord it a very low profile indeed. Dr. A Thiermann showed the picture in the ''Independent'' with cattle being incinerated and thought this was a fanatical incident to be avoided in the US at all costs. ...

http://web.archive.org/web/200603070635 ... /tab01.pdf

snip...see full text ;

SEE CWD HIGH INFECTION RATE MAPS FOR COLORADO !

http://chronic-wasting-disease.blogspot ... e-cwd.html

Tuesday, May 03, 2016

Arkansas Chronic Wasting Disease CWD TSE Prion and Elk Restoration Project and Hunkering Down in the BSE Situation Room USDA 1998

http://chronic-wasting-disease.blogspot ... e-cwd.html


TSS
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Re: Chronic Wasting Disease CWD roundup

Postby hopalong » Fri May 06, 2016 4:35 pm

NAH tss she died because she was disappointed in her high school drop son who pretends he is a DR... Embarrassed because she had to explain to her friends what a loser he was!!!!
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Re: Chronic Wasting Disease CWD roundup

Postby TennesseeTuxedo » Fri May 06, 2016 5:21 pm

Ya'll had to go and feed him didn't you?
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Re: Chronic Wasting Disease CWD roundup

Postby hopalong » Tue May 10, 2016 1:27 pm

and where in all that BULL CRAP you post show what your mother died from,,,, all we have is your word is worth CRAP
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Re: Chronic Wasting Disease CWD roundup

Postby flounder » Tue May 10, 2016 5:02 pm

Tuesday, May 10, 2016

2015 PDA Virus & TSE Safety Forum Meeting Report

>>>Recently transmission of prions from blood of patients with sporadic CJD to humanized mice could be demonstrated.<<<

>>>Further-on, urine samples of a control population (normal and neurological population) showed no signal in the study; *** however, in samples from patients with sporadic CJD and vCJD, a signal was detected in both patient populations.<<<

Meeting Report: 2015 PDA Virus & TSE Safety Forum

http://transmissiblespongiformencephalo ... eting.html

Monday, May 09, 2016

A comparison of classical and H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism in wild type and EK211 cattle following intracranial inoculation

http://bse-atypical.blogspot.com/2016/0 ... -type.html


carry on...

kind regards, terry
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Re: Chronic Wasting Disease CWD roundup

Postby hopalong » Wed May 11, 2016 10:29 am

So you have NO proof eh TERRY?? just your normal BULLshite
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Re: Chronic Wasting Disease CWD roundup

Postby flounder » Wed May 11, 2016 10:40 am

pay attention hopalong, pay attention, or is that not possible for hopalong?

got an autopsy and a second confirmation from CWRU, confirming hvCJD, and it was in one of the last postings urls. I am not going to hand feed you, because really, you and others in the business here simply don't care. ...

Wednesday, May 11, 2016

CERVID TO HUMAN PRION TRANSMISSION

http://chronic-wasting-disease.blogspot ... ssion.html

carry on hopalong, because you do your business/INDUSTRY the justice it deserves... LMAO!!!

kind regards, terry
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