MLV study

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Chocolate Cow2
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MLV study

Postby Chocolate Cow2 » Sun Apr 08, 2018 2:29 pm

MLV Reproductive Research
Research re-evaluates effect of modified-live vaccines on beef females’ reproductive performance.

by Kindra Gordon, field editor

What management steps can producers take to improve reproductive efficiency in heifers and cows? This is a question to which South Dakota State University (SDSU) Associate Professor and Extension Beef Reproductive Specialist George Perry is continuously seeking answers. Perry has long been an advocate that even small gains of 5% to 10% in reproductive efficiency can translate to more calves born — and more profit potential for producers.

Most recently, Perry and his colleagues at SDSU have been evaluating the effect of vaccinations against infectious diseases, specifically bovine viral diarrhea (BVD) and infectious bovine rhinotracheitis (IBR), and the resulting impact on reproductive efficiency. Perry shared highlights from their research findings with those attending the 2017 Range Beef Cow Symposium (RBCS) hosted in Cheyenne, Wyo., Nov. 28-30.

Many current management protocols have suggested that inactivated (killed) and modified-live virus (MLV) vaccines can both be safely administered to replacement females 30 days prior to the start of the breeding season and as an annual booster to cows. Plus, conventional wisdom has suggested the MLV actually provided better immunity protection.

However, Perry shared a review of several reproduction studies with RBCS attendees suggesting administration of the MLV vaccine, even when given at labeled prebreeding intervals, may negatively affect reproductive parameters compared to cattle vaccinated with inactivated vaccines. Additionally, research indicates the MLV vaccine does not appear to offer superior immunity protection.

Perry shared a review of several reproduction studies with RBCS attendees suggesting administration of the MLV vaccine, even when given at labeled prebreeding intervals, may negatively affect reproductive parameters compared to cattle vaccinated with inactivated vaccines. Additionally, research indicates the MLV vaccine does not appear to offer superior immunity protection.

Perry hypothesizes that the negative effect of the MLV vaccine may be impacting development of the egg as it is grown by the follicle in the 90-day period prior to ovulation and fertilization. He added, “Right now I can’t tell you what’s causing those negative effects. We have studies trying to identify that.”

With this new research coming to light, more investigation is needed, and Perry and his colleagues are pursuing additional research. In the meantime, Perry shared this advice with producers, “Modified-live vaccines have their place to prime the immune system.”
He suggested an MLV vaccine is best administered to calves at weaning. Then, for replacement females prebreeding, Perry suggests switching to an inactivated/killed vaccine. For the cow herd Perry advises using a killed vaccine booster annually for disease protection.

He noted that this protocol — using an MLV vaccine at weaning and an inactivated vaccine prebreeding — activates both sides of the immune system.

That said, Perry called it “critical” for producers to gain input from their herd veterinarian before making changes to their vaccination products or timing.

He noted, “Prevention needs differ among herds and depend on the virus loads that herds are exposed to.”
He also explained that none of the pre-breeding studies from which he shared data were carried out in the face of disease challenge and did not address the question of protection in the face of an infectious reproductive disease exposure.
Perry advised producers to monitor future research findings to help determine the best balance to achieve appropriate disease protection and minimize harmful effects from the vaccines themselves.
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Stocker Steve
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Re: MLV study

Postby Stocker Steve » Sun Apr 08, 2018 2:36 pm

Yes.
Good post.
I have gone to Bova Shield after weaning and Triangle Ten after that.
I get about 1% late pregnancy abortions, but I don't think vaccine is the issue.
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Bright Raven
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Re: MLV study

Postby Bright Raven » Sun Apr 08, 2018 2:57 pm

A very similar report was published in The Kentucky Cattleman. [I posted the reference here but cannot find it]. The modified live viruses of IBR contained in the vaccine go to the ovary and disrupt the estrus cycle. The publication recommended vaccination 60 days PRIOR to breeding rather than 30 days PRIOR to breeding to allow the ovary to adjust to the disruption. The publication recommended MLV Fetal Protection vaccines because they continue to suggest that you get a better immune response.

Edited to add:

I found the post:
In the circumstances you provided, the cow is open, obviously, without saying, there is no danger of abortion. Personally, I would give her 5 days postpartum to adjust then vaccinate. However, some recent research on MLV Vaccines was reported to interfere with ovary cycles (Dr. Michelle Arnold, University of Kentucky). So you should be aware of that and give the cow 4 to 6 weeks to react to the vaccine before breeding her back.
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Re: MLV study

Postby Chocolate Cow2 » Sun Apr 08, 2018 5:05 pm

If I am reading correctly, the article I posted says MLV is disruptive for 90 days.
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Re: MLV study

Postby Bright Raven » Mon Apr 09, 2018 6:21 am

Chocolate Cow2 wrote:If I am reading correctly, the article I posted says MLV is disruptive for 90 days.


That is not exactly what it says - although it MAY.

Perry hypothesizes that the negative effect of the MLV vaccine may be impacting development of the egg as it is grown by the follicle in the 90-day period prior to ovulation and fertilization.

The maturation of the follicle, called folliculogenesis, is a period prior to the follicle becoming a mature follicle and releasing an egg. The MLV IBR component is the one that MAY influence the development of the follicle. It is not saying how long that occurs. If that follicle is 30 days from rupture and releasing an egg, it might be affected.

I would stick with 60 days PRIOR to breeding. If you open that window wider, the immunity might diminish.

BTW: the report I read said only the IBR component influences the egg. The BVD component was not indicted.
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