WAHIS Brazil Bovine spongiform encephalopathy Follow up report 1 [FINAL]
Brazil - Bovine spongiform encephalopathy - Follow up report 1 [FINAL]
GENERAL INFORMATION
COUNTRY/TERRITORY OR ZONE
COUNTRY/TERRITORY
ANIMAL TYPE TERRESTRIAL
DISEASE CATEGORY OIE-listed
EVENT ID 4918
DISEASE Bovine spongiform encephalopathy
CAUSAL AGENT Bovine spongiform encephalopathy prion, atypical strain, H-type
GENOTYPE / SEROTYPE / SUBTYPE -
START DATE 2023/01/18
REASON FOR NOTIFICATION Recurrence of an eradicated disease
DATE OF LAST OCCURRENCE 2021/09/03
CONFIRMATION DATE 2023/02/22
EVENT STATUS Resolved
END DATE 2023/03/03
SELF-DECLARATION NO
REPORT INFORMATION REPORT NUMBER Follow-up report 1
REPORT ID FUR_159644
REPORT REFERENCE -
REPORT DATE 2023/03/05
REPORT STATUS Validated
NO EVOLUTION REPORT -
EPIDEMIOLOGY
SOURCE OF EVENT OR ORIGIN OF INFECTION
Unknown or inconclusive
EPIDEMIOLOGICAL COMMENTS
On March 3rd, 2023, the National Centre for Animal Diseases/Canadian Food Inspection Agency (NCAD/CFIA), Lethbridge Laboratory, WOAH reference laboratory, issued a conclusive result of the Western Blotting test with atypical H-type BSE detected. This is the sixth case of atypical H-type BSE registered in Brazil in more than 25 years of surveillance for the disease. Brazil has never diagnosed a classical BSE case, maintaining, since 2012, official recognition by the WOAH as a country of negligible risk for the disease. The investigation has been completed.
QUANTITATIVE DATA SUMMARY MEASURING UNIT Animal
Species Susceptible Cases Deaths Killed and Disposed of Slaughtered/ Killed for commercial use Vaccinated
Cattle (DOMESTIC) NEW------
TOTAL160 1 0 1 0 0 DIAGNOSTIC DETAILS CLINICAL SIGNS YES
METHOD OF DIAGNOSTIC Diagnostic test
Test name Laboratory Species sampled Number of outbreaks sampled First result date Latest result date Result
Antigen detection Western blot (Ag Western blot) Canadian Food Inspection Agency (CFIA), National Centre for Animal Disease (NCAD), Lethbridge Laboratory Cattle 1 2023/03/03 2023/03/03 Positive
Immunohistochemistry (IHC) Laboratorio Federal de Defesa Agropecuária - PE Cattle 1 2023/02/22 2023/02/22 Positive
CONTROL MEASURES AT EVENT LEVEL
CONTROL MEASURES AT EVENT LEVEL
DOMESTIC ANIMALS
WILD ANIMALS
Official disposal of carcasses, by-products and waste
Applied
Screening
Applied
Selective killing and disposal
Applied
Traceability
Applied
PREVIOUSLY REPORTED OUTBREAKS
OB_114504 - 15042080057 - MARABÁ
https://wahis.woah.org/#/in-review/4918
''H-TYPE BSE AGENT IS TRANSMISSIBLE BY THE ORONASAL ROUTE''
This study demonstrates that the H-type BSE agent is transmissible by the oronasal route. These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094
OIE Conclusions on transmissibility of atypical BSE among cattle
Given that cattle have been successfully infected by the oral route, at least for L-BSE, it is reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle are exposed to contaminated feed. In addition, based on reports of atypical BSE from several countries that have not had C-BSE, it appears likely that atypical BSE would arise as a spontaneous disease in any country, albeit at a very low incidence in old cattle. In the presence of livestock industry practices that would allow it to be recycled in the cattle feed chain, it is likely that some level of exposure and transmission may occur. As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.
https://www.oie.int/fileadmin/SST/a...alopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf
Annex 7 (contd) AHG on BSE risk assessment and surveillance/March 2019
34 Scientific Commission/September 2019
3. Atypical BSE
The Group discussed and endorsed with minor revisions an overview of relevant literature on the risk of atypical BSE being recycled in a cattle population and its zoonotic potential that had been prepared ahead of the meeting by one expert from the Group. This overview is provided as Appendix IV and its main conclusions are outlined below. With regard to the risk of recycling of atypical BSE, recently published research confirmed that the L-type BSE prion (a type of atypical BSE prion) may be orally transmitted to calves1 . In light of this evidence, and the likelihood that atypical BSE could arise as a spontaneous disease in any country, albeit at a very low incidence, the Group was of the opinion that it would be reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle were to be exposed to contaminated feed. Therefore, the recycling of atypical strains in cattle and broader ruminant populations should be avoided.
The Group acknowledged the challenges in demonstrating the zoonotic transmission of atypical strains of BSE in natural exposure scenarios. Overall, the Group was of the opinion that, at this stage, it would be premature to reach a conclusion other than that atypical BSE poses a potential zoonotic risk that may be different between atypical strains.
4. Definitions of meat-and-bone meal (MBM) and greaves
snip...
REFERENCES
SNIP...END SEE FULL TEXT;
http://web.oie.int/downld/PROC2020/A_SCAD_Sept2019.pdf
Consumption of L-BSE–contaminated feed may pose a risk for oral transmission of the disease agent to cattle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324790/
Thus, it is imperative to maintain measures that prevent the entry of tissues from cattle possibly infected with the agent of L-BSE into the food chain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310119/
Brazil MAPA OMSA Confirms BSE TSE Prion atypical H-type
OFFICIAL NOTE - Map confirms that case of Bovine Spongiform Encephalopathy is atypical type H
Ministry is immediately adopting measures so that exports of Brazilian beef are reestablished as soon as possible
Published on 03/02/2023 22:18 Updated on 03/03/2023 00:08
https://www.gov.br/agricultura/pt-b...e-encefalopatia-espongiforme-bovina-e-atipico
Brazil Confirms BSE Mad Cow Case, Strain not known yet
OFFICIAL NOTE
Mapa adopts measures on BSE case in Brazil
Meat for market consumption is not affected by confirmation
Published on 02/22/2023 8:15 pm Updated on 02/22/2023 9:51 pm
https://www.gov.br/agricultura/pt-b...ta-providencias-sobre-caso-de-eeb-no-brasil-1
Brazil Suspected case of bovine spongiform encephalopathy
COMUNICADO
Caso suspeito de Encefalopatia Espongiforme Bovina
para Copiar para área de transferência Publicado em 20/02/2023 15h36
Atualizado em 20/02/2023 15h39 O
https://www.gov.br/agricultura/pt-b...suspeito-de-encefalopatia-espongiforme-bovina
2023/01/18
EVENT 4918
Brazil - Bovine spongiform encephalopathy
https://wahis.woah.org/#/in-event/4918/dashboard
Brazil - Bovine spongiform encephalopathy - Follow up report 1 [FINAL]
GENERAL INFORMATION
COUNTRY/TERRITORY OR ZONE
COUNTRY/TERRITORY
ANIMAL TYPE TERRESTRIAL
DISEASE CATEGORY OIE-listed
EVENT ID 4918
DISEASE Bovine spongiform encephalopathy
CAUSAL AGENT Bovine spongiform encephalopathy prion, atypical strain, H-type
GENOTYPE / SEROTYPE / SUBTYPE -
START DATE 2023/01/18
REASON FOR NOTIFICATION Recurrence of an eradicated disease
DATE OF LAST OCCURRENCE 2021/09/03
CONFIRMATION DATE 2023/02/22
EVENT STATUS Resolved
END DATE 2023/03/03
SELF-DECLARATION NO
REPORT INFORMATION REPORT NUMBER Follow-up report 1
REPORT ID FUR_159644
REPORT REFERENCE -
REPORT DATE 2023/03/05
REPORT STATUS Validated
NO EVOLUTION REPORT -
EPIDEMIOLOGY
SOURCE OF EVENT OR ORIGIN OF INFECTION
Unknown or inconclusive
EPIDEMIOLOGICAL COMMENTS
On March 3rd, 2023, the National Centre for Animal Diseases/Canadian Food Inspection Agency (NCAD/CFIA), Lethbridge Laboratory, WOAH reference laboratory, issued a conclusive result of the Western Blotting test with atypical H-type BSE detected. This is the sixth case of atypical H-type BSE registered in Brazil in more than 25 years of surveillance for the disease. Brazil has never diagnosed a classical BSE case, maintaining, since 2012, official recognition by the WOAH as a country of negligible risk for the disease. The investigation has been completed.
QUANTITATIVE DATA SUMMARY MEASURING UNIT Animal
Species Susceptible Cases Deaths Killed and Disposed of Slaughtered/ Killed for commercial use Vaccinated
Cattle (DOMESTIC) NEW------
TOTAL160 1 0 1 0 0 DIAGNOSTIC DETAILS CLINICAL SIGNS YES
METHOD OF DIAGNOSTIC Diagnostic test
Test name Laboratory Species sampled Number of outbreaks sampled First result date Latest result date Result
Antigen detection Western blot (Ag Western blot) Canadian Food Inspection Agency (CFIA), National Centre for Animal Disease (NCAD), Lethbridge Laboratory Cattle 1 2023/03/03 2023/03/03 Positive
Immunohistochemistry (IHC) Laboratorio Federal de Defesa Agropecuária - PE Cattle 1 2023/02/22 2023/02/22 Positive
CONTROL MEASURES AT EVENT LEVEL
CONTROL MEASURES AT EVENT LEVEL
DOMESTIC ANIMALS
WILD ANIMALS
Official disposal of carcasses, by-products and waste
Applied
Screening
Applied
Selective killing and disposal
Applied
Traceability
Applied
PREVIOUSLY REPORTED OUTBREAKS
OB_114504 - 15042080057 - MARABÁ
https://wahis.woah.org/#/in-review/4918
''H-TYPE BSE AGENT IS TRANSMISSIBLE BY THE ORONASAL ROUTE''
This study demonstrates that the H-type BSE agent is transmissible by the oronasal route. These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094
OIE Conclusions on transmissibility of atypical BSE among cattle
Given that cattle have been successfully infected by the oral route, at least for L-BSE, it is reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle are exposed to contaminated feed. In addition, based on reports of atypical BSE from several countries that have not had C-BSE, it appears likely that atypical BSE would arise as a spontaneous disease in any country, albeit at a very low incidence in old cattle. In the presence of livestock industry practices that would allow it to be recycled in the cattle feed chain, it is likely that some level of exposure and transmission may occur. As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.
https://www.oie.int/fileadmin/SST/a...alopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf
Annex 7 (contd) AHG on BSE risk assessment and surveillance/March 2019
34 Scientific Commission/September 2019
3. Atypical BSE
The Group discussed and endorsed with minor revisions an overview of relevant literature on the risk of atypical BSE being recycled in a cattle population and its zoonotic potential that had been prepared ahead of the meeting by one expert from the Group. This overview is provided as Appendix IV and its main conclusions are outlined below. With regard to the risk of recycling of atypical BSE, recently published research confirmed that the L-type BSE prion (a type of atypical BSE prion) may be orally transmitted to calves1 . In light of this evidence, and the likelihood that atypical BSE could arise as a spontaneous disease in any country, albeit at a very low incidence, the Group was of the opinion that it would be reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle were to be exposed to contaminated feed. Therefore, the recycling of atypical strains in cattle and broader ruminant populations should be avoided.
The Group acknowledged the challenges in demonstrating the zoonotic transmission of atypical strains of BSE in natural exposure scenarios. Overall, the Group was of the opinion that, at this stage, it would be premature to reach a conclusion other than that atypical BSE poses a potential zoonotic risk that may be different between atypical strains.
4. Definitions of meat-and-bone meal (MBM) and greaves
snip...
REFERENCES
SNIP...END SEE FULL TEXT;
http://web.oie.int/downld/PROC2020/A_SCAD_Sept2019.pdf
Consumption of L-BSE–contaminated feed may pose a risk for oral transmission of the disease agent to cattle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324790/
Thus, it is imperative to maintain measures that prevent the entry of tissues from cattle possibly infected with the agent of L-BSE into the food chain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310119/
Brazil MAPA OMSA Confirms BSE TSE Prion atypical H-type
OFFICIAL NOTE - Map confirms that case of Bovine Spongiform Encephalopathy is atypical type H
Ministry is immediately adopting measures so that exports of Brazilian beef are reestablished as soon as possible
Published on 03/02/2023 22:18 Updated on 03/03/2023 00:08
https://www.gov.br/agricultura/pt-b...e-encefalopatia-espongiforme-bovina-e-atipico
Brazil Confirms BSE Mad Cow Case, Strain not known yet
OFFICIAL NOTE
Mapa adopts measures on BSE case in Brazil
Meat for market consumption is not affected by confirmation
Published on 02/22/2023 8:15 pm Updated on 02/22/2023 9:51 pm
https://www.gov.br/agricultura/pt-b...ta-providencias-sobre-caso-de-eeb-no-brasil-1
Brazil Suspected case of bovine spongiform encephalopathy
COMUNICADO
Caso suspeito de Encefalopatia Espongiforme Bovina
para Copiar para área de transferência Publicado em 20/02/2023 15h36
Atualizado em 20/02/2023 15h39 O
https://www.gov.br/agricultura/pt-b...suspeito-de-encefalopatia-espongiforme-bovina
2023/01/18
EVENT 4918
Brazil - Bovine spongiform encephalopathy
https://wahis.woah.org/#/in-event/4918/dashboard
